Phytochemical Screening and Therapeutic Effects of Binahong (Anredera cordifolia (Ten.) Steenis) Leaves
Keywords:
Binahong leaves, Anredera cordifolia, phytochemical screening, therapeutic effects
Abstract
In this review, the function of secondary metabolites in Binahong (Anredera cordifolia (Ten.) Steenis) leaves were summarized for their therapeutic effects such as antimicrobial activity, anti-inflammatory, wound healing, lowering the blood pressure, and antihyperlipidemic activity as a potential medicinal plant to treat disease. The phytochemical screening of Binahong leaves extracted by using particular solvent showed positive results to the presence of phenolic, steroid, terpenoid, alkaloid, and saponin compounds contained in the extract. The antimicrobial activity is able to disrupt cell membrane activity and inhibit bacterial growth, meanwhile anti-inflammatory ability is able to decrease anti-inflammatory agents level. It also decreases blood pressure by regulation of lipid metabolites, reduction of peripheral resistance, and upregulation of nitric oxide activity. The ethanolic extract of Binahong leaves can reduce fat deposits or layers in the endothelial cells, cholesterol, triglycerides, and low-density lipoprotein (LDL) cholesterol levels, and decrease the levels of malondialdehyde (MDA formation) from the lipid peroxidation to prevent hyperlipidemia and heart disease.
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References
Abidin, T., Hanafiah, O., Hanafiah, D., Bayu, E.,
Ilyas, S., Nainggolan, M., & Syamsudin, E.
(2017). Quantity differences of secondary
metabolites (saponins, tannins, and
flavonoids) from Binahong plant extract
(Anredera cordifolia (Ten.) Steenis) treated
and untreated with colchicines that play a
role in wound healing. World Journal of
Dentistry, 8(4), 296-299. doi:10.5005/jpjournals-10015-1453
Aditia, D. S., Hidayat, S. T., Khafidhoh, N.,
Suhartono, S., & Suwondo, A. (2017).
Binahong leaves (Anredera cordifolia (Ten.)
Steenis) extract as an alternative treatment
for perineal wound healing of postpartum
mothers. Belitung Nursing Journal, 3(6), 778-
783. doi:10.33546/bnj.290
Ahn, K. (2017). The worldwide trend of using
botanical drugs and strategies for developing
global drugs. BMB Reports, 50(3), 111-116.
doi:10.5483/bmbrep.2017.50.3.221
Alfisana, A. (2020). Daun Binahong (Anredera
Cordifolia) Obat Herbal Sebagai Antibakteri -.
Retrieved 4 January 2021, from
Indonesian Journal of Life Sciences Vol. 03 | No. 02 | September 2021
http://journal.i3l.ac.id/index.php/IJLS
53
http://farmasi.unida.gontor.ac.id/2020/07/3
0/daun-Binahong-anredera-cordifolia-obatherbal-sebagai-antibakteri/
American Diabetes Association (2011). Diagnosis
and classification of diabetes mellitus.
Diabetes care, 34(Suppl 1), S62–S69.
doi:10.2337/dc11-S062
Ariani, S., Loho, L., & Durry, M. F. (2014). Khasiat
daun Binahong (Anredera cordifolia (ten.)
Steenis) terhadap pembentukan jaringan
granulasi dan re-epitelisasi penyembuhan
luka terbuka kulit kelinci. eBiomedik, 1(2).
doi:10.35790/ebm.1.2.2013.3250
Babii, C., Bahrin, L. G., Neagu, A.N., Gostin, I.,
Mihasan, M., Birsa, L. M., & Stefan, M. (2016).
Antibacterial activity and proposed action
mechanism of a new class of synthetic
tricyclic flavonoids. Journal of Applied
Microbiology, 120(3), 630–637.
doi:10.1111/jam.13048
Basyuni, M., Baba, S., Kinjo, Y., Putri, L. A. P.,
Hakim, L., & Oku, H. (2012). Salt-dependent
increase in triterpenoids is reversible upon
transfer to fresh water in mangrove plants
Kandelia candel and Bruguiera gymnorrhiza.
Journal of Plant Physiology, 169(18), 1903–
1908. doi:10.1016/j.jplph.2012.08.005
Basyuni, M., Ginting, P., & Lesmana, I. (2017).
Phytochemical analysis of Binahong
(Anredera Cordifolia) leaves extract to inhibit
in vitro growth of Aeromonas hydrophila. AIP
Conference Proceedings 1904, 020072.
doi:10.1063/1.5011929
Berniyanti, T., & Mahmiyah, E. (2015).
Microbiological studies on the production of
antimicrobial agent by saponin aloe vera linn
against Streptococcus sanguinis. Research
Journal of Microbiology, 10, 385-392.
doi:10.3923/jm.2015.385.392
CABI. (2020). Anredera cordifolia (Madeira vine).
Retrieved 20 December 2020, from
https://www.cabi.org/isc/datasheet/112290
Garmana, A., Sukandar, E., & Fidrianny, I. (2018).
Antihypertension study of Anredera
cordifolia (Ten). V. Steenis extract and its
fractions in rats through dexamethasone
induction and nitric oxide release. Asian
Journal of Pharmaceutical and Clinical
Research, 11(1), 278.
doi:10.22159/ajpcr.2018.v11i1.22312
Garmana, A., Sukandar, E., & Fidrianny, I. (2016).
Preliminary study of blood pressure lowering
effect of Anredera cordifolia (Ten.) Steenis)
on wistar rats. International Journal of
Pharmacognosy and Phytochemical
Research, 8(2), 300-304.
Javed, B., Nawaz, K., & Munazir, M. (2020).
Phytochemical analysis and antibacterial
activity of tannins extracted from Salix alba L.
against different gram-positive and gramnegative bacterial strains. Iranian Journal of
Science and Technology, Transactions A:
Science. doi:10.1007/s40995-020-00937-w
Hidayat, R., & Napitupulu, R. (2015). Kitab
Tumbuhan Obat. Jakarta Timur: AgriFlo
(Penebar Swadaya Grup).
Iskandar, N., & Iriawati, I. (2016). Vinblastine and
vincristine production on madagascar
periwinkle (Catharanthus roseus (L.) G. Don)
Callus culture treated with polyethylene
glycol. Makara Journal of Science, 20(1).
doi:10.7454/mss.v20i1.5656
Khan, M.I., Ahhmed, A., Shin, J.H., Baek, J.S., Kim,
M.Y., & Kim, J.D. (2018). Green tea seed
isolated saponins exerts antibacterial effects
against various strains of gram positive and
gram negative bacteria, a comprehensive
study in vitro and in vivo. Evidence-Based
Complementary and Alternative Medicine,
Indonesian Journal of Life Sciences Vol. 03 | No. 02 | September 2021
http://journal.i3l.ac.id/index.php/IJLS
54
vol. 2018, Article ID 3486106, 12 pages.
doi:10.1155/2018/3486106
Kim, M., Han, C., & Lee, M. (2014). Enhancement
of platelet aggregation by ursolic acid and
oleanolic acid. Biomolecules & Therapeutics,
22(3), 254-259.
doi:10.4062/biomolther.2014.008
Kismiati, S., Wahyuni, H. I., Muryani, R., Sunarti,
D., & Sumarsih, S. (2020). Addition of
Binahong (Anredera cordifolia) leaf powder
to diets to produce eggs with low cholesterol,
Veterinary World, 13(3), 604-608.
doi:10.14202/vetworld.2020.604-608
Kurniawan, B., Carolia, N., & Pheilia, A. (2014).
The effectiveness of Binahong leaf extract
(Anredera Cordifolia (Ten.) Steenis) and
mefenamic acid as anti-inflammation to
white male rat induced by karagenin. JUKE,
4(8), 151-157.
Laksmitawati, D.R., Widyastuti, A., Karami, N.,
Afifah, E., Rihibiha, D.D., Nufus, H., Widowati,
W. (2017). Antiinflammatory effects of
Anredera cordifolia and Piper crocatum
extracts on lipopolysaccharide-stimulated
macrophage cell line. Bangladesh J
Pharmacol, 12, 35-40.
doi:10.3329/bjp.v12i1.28714
Lestari, D., Sukandar, E. Y., & Fidrianny, I. (2016).
Anredera cordifolia leaves fraction as an
antihyperlipidemia. Asian J Pharm Clin Res,
9(6), 82-84.
doi:10.22159/ajpcr.2016.v9i6.13628
Lestari, R. P., Nissa, C., Afifah, D. N., Anjani, G., &
Rustanti, N. (2018). Total lactic acid bacteria
(LAB), antioxidant activity, and acceptance of
synbiotic yoghurt with Binahong leaf extract
(Anredera cordifolia (Ten.) Steenis). IOP
Conference Series: Earth and Environmental
Science. doi:10.1088/1755-
1315/116/1/012033
Mabhiza, D., Chitemerere, T., & Mukanganyama,
S. (2016). Antibacterial properties of alkaloid
extracts from Callistemon citrinus and
Vernonia adoensis against Staphylococcus
aureus and Pseudomonas aeruginosa.
International Journal of Medicinal Chemistry,
2016, Article ID 6304163, 7 pages.
doi:10.1155/2016/6304163
Maharani, E.S., Puspitawati, R., & Gunawan, H.A.
(2018). Antibacterial effect of Binahong
(Anredera cordifolia (Ten.) Steenis) leaf
infusion against black pigmented bacteria. J.
Phys.: Conf. Ser, 1073, 032013.
doi:10.1088/1742-6596/1073/3/032013
Patil, S., Bachhav, S., Bhutada, M., Patil, S., &
Sharma, K. (2015). Oleanolic acid prevents
increase in blood pressure and nephrotoxicity
in nitric oxide dependent type of
hypertension in rats. Pharmacognosy
Research, 7(4), 385. doi:10.4103/0974-
8490.159575
PIER. (2013). Anredera cordifolia: info from PIER
(PIER species info). Retrieved in 19 December
2020 from
http://www.hear.org/pier/species/anredera
_cordifolia.htm
Nagappan, R. (2012). Evaluation of aqueous and
ethanol extract of bioactive medicinal plant,
Cassia didymobotrya (Fresenius) Irwin &
Barneby against immature stages of filarial
vector, Culex quinquefasciatus Say (Diptera:
Culicidae). Asian Pacific Journal of Tropical
Biomedicine, 2(9), 707–711.
doi:10.1016/s2221-1691(12)60214-7
Nisar, B., Sultan, A., & Rubab, S. (2018).
Comparison of Medicinally Important Natural
Products versus Synthetic Drugs-A Short
Commentary. Natural Products Chemistry &
Research, 6(2). doi:10.4172/2329-
6836.1000308
Indonesian Journal of Life Sciences Vol. 03 | No. 02 | September 2021
http://journal.i3l.ac.id/index.php/IJLS
55
Nury, D. F., Widjaja, T., & Kurniawan, F. (2019).
The effect of Binahong (Anredera cordifolia
(Ten.) Steenis) medicinal plant extract
addition on glucose detection. Jurnal Sains
dan Seni ITS, 8(2), C15-C20.
doi:10.12962/j23373520.v8i2.49944
Serban, M., Sahebkar, A., Zanchetti, A.,
Mikhailidis, D., Howard, G., & Antal, D. et al.
(2016). Effects of quercetin on blood
pressure: a systematic review and meta‐
analysis of randomized controlled trials.
Journal of The American Heart Association,
5(7). doi:10.1161/jaha.115.002713
Setyowati, W.A.E.., Nurisah, R,P., & Wulandari,
P.I. (2020). Binahong leaves water extract
(Anredera Cordifolia (Tenore) Steen.) as a
natural foaming and antibacterial agent of
antiseptic liquid bath soap. JKPK (Jurnal Kimia
dan Pendidikan Kimia), 5(2).
doi:10.20961/jkpk.v5i2.29892
Sutrisno, E., Adnyana I, K., Yulinah Sukandar, E.,
Fidrianny, I., & Aligita, W. (2016). Antiinflammatory study of Anredera Cordifolia
leaves and Centella Asiatica herbs and its
combinations using human red blood cellmembrane stabilization method. Asian
Journal of Pharmaceutical and Clinical
Research, 9(5), 78. doi:10.22159/ajpcr.
2016.v9i5.11973
Syahfery, I., Nasution, A.H., Satria, D., Ervina, I.,
& Hanafiah, O.A. (2020). Evaluation of IL-6
levels after subgingival application Binahong
leaf extract gel 3% on patients of chronic
periodontitis. International Journal of Applied
Dental Sciences, 6(3), 615-618.
doi:10.22271/oral.2020.v6.i3i.1016
USDA. (2015). Plants Profile for Anredera
cordifolia (heartleaf madeiravine). Retrieved
in 19 December 2020 from
https://plants.usda.gov/core/profile?symbol
=anco6
Wahjuni, S. (2014). Anti-hipercholesterolemia of
Anredera cordifolia in hypercholesterolemia
rat wistar through decrease of
malondialdehyde and 8-hydroxydiguanosine. Indonesian Journal of
Biomedical Science, 8(1), 4-7.
doi:10.15562/ijbs.v8i1.7
Yang, R. L., Shi, Y. H., Hao, G., Li, W., & Le, G. W.
(2008). Increasing oxidative stress with
progressive hyperlipidemia in human:
relation between malondialdehyde and
atherogenic index. Journal of Clinical
Biochemistry and Nutrition, 43(3), 154-158.
doi:10.3164/jcbn.2008044
Yuniarti, W., & Lukiswanto, B. (2017). Effects of
herbal ointment containing the leaf extracts
of Madeira vine (Anredera cordifolia (Ten.)
Steenis) for burn wound healing process on
albino rats. Veterinary World, 10(7), 808-813.
doi:10.14202/vetworld.2017.808-813
Zhang, S., Liu, Y., Wang, X., Tian, Z., Qi, D., Li, Y.,
& Jiang, H. (2020). Antihypertensive activity
of oleanolic acid is mediated via
downregulation of secretory phospholipase
A2 and fatty acid synthase in spontaneously
hypertensive rats. International Journal of
Molecular Medicine, 46(6), 2019-2034.
doi:10.3892/ijmm.2020.4744
Ilyas, S., Nainggolan, M., & Syamsudin, E.
(2017). Quantity differences of secondary
metabolites (saponins, tannins, and
flavonoids) from Binahong plant extract
(Anredera cordifolia (Ten.) Steenis) treated
and untreated with colchicines that play a
role in wound healing. World Journal of
Dentistry, 8(4), 296-299. doi:10.5005/jpjournals-10015-1453
Aditia, D. S., Hidayat, S. T., Khafidhoh, N.,
Suhartono, S., & Suwondo, A. (2017).
Binahong leaves (Anredera cordifolia (Ten.)
Steenis) extract as an alternative treatment
for perineal wound healing of postpartum
mothers. Belitung Nursing Journal, 3(6), 778-
783. doi:10.33546/bnj.290
Ahn, K. (2017). The worldwide trend of using
botanical drugs and strategies for developing
global drugs. BMB Reports, 50(3), 111-116.
doi:10.5483/bmbrep.2017.50.3.221
Alfisana, A. (2020). Daun Binahong (Anredera
Cordifolia) Obat Herbal Sebagai Antibakteri -.
Retrieved 4 January 2021, from
Indonesian Journal of Life Sciences Vol. 03 | No. 02 | September 2021
http://journal.i3l.ac.id/index.php/IJLS
53
http://farmasi.unida.gontor.ac.id/2020/07/3
0/daun-Binahong-anredera-cordifolia-obatherbal-sebagai-antibakteri/
American Diabetes Association (2011). Diagnosis
and classification of diabetes mellitus.
Diabetes care, 34(Suppl 1), S62–S69.
doi:10.2337/dc11-S062
Ariani, S., Loho, L., & Durry, M. F. (2014). Khasiat
daun Binahong (Anredera cordifolia (ten.)
Steenis) terhadap pembentukan jaringan
granulasi dan re-epitelisasi penyembuhan
luka terbuka kulit kelinci. eBiomedik, 1(2).
doi:10.35790/ebm.1.2.2013.3250
Babii, C., Bahrin, L. G., Neagu, A.N., Gostin, I.,
Mihasan, M., Birsa, L. M., & Stefan, M. (2016).
Antibacterial activity and proposed action
mechanism of a new class of synthetic
tricyclic flavonoids. Journal of Applied
Microbiology, 120(3), 630–637.
doi:10.1111/jam.13048
Basyuni, M., Baba, S., Kinjo, Y., Putri, L. A. P.,
Hakim, L., & Oku, H. (2012). Salt-dependent
increase in triterpenoids is reversible upon
transfer to fresh water in mangrove plants
Kandelia candel and Bruguiera gymnorrhiza.
Journal of Plant Physiology, 169(18), 1903–
1908. doi:10.1016/j.jplph.2012.08.005
Basyuni, M., Ginting, P., & Lesmana, I. (2017).
Phytochemical analysis of Binahong
(Anredera Cordifolia) leaves extract to inhibit
in vitro growth of Aeromonas hydrophila. AIP
Conference Proceedings 1904, 020072.
doi:10.1063/1.5011929
Berniyanti, T., & Mahmiyah, E. (2015).
Microbiological studies on the production of
antimicrobial agent by saponin aloe vera linn
against Streptococcus sanguinis. Research
Journal of Microbiology, 10, 385-392.
doi:10.3923/jm.2015.385.392
CABI. (2020). Anredera cordifolia (Madeira vine).
Retrieved 20 December 2020, from
https://www.cabi.org/isc/datasheet/112290
Garmana, A., Sukandar, E., & Fidrianny, I. (2018).
Antihypertension study of Anredera
cordifolia (Ten). V. Steenis extract and its
fractions in rats through dexamethasone
induction and nitric oxide release. Asian
Journal of Pharmaceutical and Clinical
Research, 11(1), 278.
doi:10.22159/ajpcr.2018.v11i1.22312
Garmana, A., Sukandar, E., & Fidrianny, I. (2016).
Preliminary study of blood pressure lowering
effect of Anredera cordifolia (Ten.) Steenis)
on wistar rats. International Journal of
Pharmacognosy and Phytochemical
Research, 8(2), 300-304.
Javed, B., Nawaz, K., & Munazir, M. (2020).
Phytochemical analysis and antibacterial
activity of tannins extracted from Salix alba L.
against different gram-positive and gramnegative bacterial strains. Iranian Journal of
Science and Technology, Transactions A:
Science. doi:10.1007/s40995-020-00937-w
Hidayat, R., & Napitupulu, R. (2015). Kitab
Tumbuhan Obat. Jakarta Timur: AgriFlo
(Penebar Swadaya Grup).
Iskandar, N., & Iriawati, I. (2016). Vinblastine and
vincristine production on madagascar
periwinkle (Catharanthus roseus (L.) G. Don)
Callus culture treated with polyethylene
glycol. Makara Journal of Science, 20(1).
doi:10.7454/mss.v20i1.5656
Khan, M.I., Ahhmed, A., Shin, J.H., Baek, J.S., Kim,
M.Y., & Kim, J.D. (2018). Green tea seed
isolated saponins exerts antibacterial effects
against various strains of gram positive and
gram negative bacteria, a comprehensive
study in vitro and in vivo. Evidence-Based
Complementary and Alternative Medicine,
Indonesian Journal of Life Sciences Vol. 03 | No. 02 | September 2021
http://journal.i3l.ac.id/index.php/IJLS
54
vol. 2018, Article ID 3486106, 12 pages.
doi:10.1155/2018/3486106
Kim, M., Han, C., & Lee, M. (2014). Enhancement
of platelet aggregation by ursolic acid and
oleanolic acid. Biomolecules & Therapeutics,
22(3), 254-259.
doi:10.4062/biomolther.2014.008
Kismiati, S., Wahyuni, H. I., Muryani, R., Sunarti,
D., & Sumarsih, S. (2020). Addition of
Binahong (Anredera cordifolia) leaf powder
to diets to produce eggs with low cholesterol,
Veterinary World, 13(3), 604-608.
doi:10.14202/vetworld.2020.604-608
Kurniawan, B., Carolia, N., & Pheilia, A. (2014).
The effectiveness of Binahong leaf extract
(Anredera Cordifolia (Ten.) Steenis) and
mefenamic acid as anti-inflammation to
white male rat induced by karagenin. JUKE,
4(8), 151-157.
Laksmitawati, D.R., Widyastuti, A., Karami, N.,
Afifah, E., Rihibiha, D.D., Nufus, H., Widowati,
W. (2017). Antiinflammatory effects of
Anredera cordifolia and Piper crocatum
extracts on lipopolysaccharide-stimulated
macrophage cell line. Bangladesh J
Pharmacol, 12, 35-40.
doi:10.3329/bjp.v12i1.28714
Lestari, D., Sukandar, E. Y., & Fidrianny, I. (2016).
Anredera cordifolia leaves fraction as an
antihyperlipidemia. Asian J Pharm Clin Res,
9(6), 82-84.
doi:10.22159/ajpcr.2016.v9i6.13628
Lestari, R. P., Nissa, C., Afifah, D. N., Anjani, G., &
Rustanti, N. (2018). Total lactic acid bacteria
(LAB), antioxidant activity, and acceptance of
synbiotic yoghurt with Binahong leaf extract
(Anredera cordifolia (Ten.) Steenis). IOP
Conference Series: Earth and Environmental
Science. doi:10.1088/1755-
1315/116/1/012033
Mabhiza, D., Chitemerere, T., & Mukanganyama,
S. (2016). Antibacterial properties of alkaloid
extracts from Callistemon citrinus and
Vernonia adoensis against Staphylococcus
aureus and Pseudomonas aeruginosa.
International Journal of Medicinal Chemistry,
2016, Article ID 6304163, 7 pages.
doi:10.1155/2016/6304163
Maharani, E.S., Puspitawati, R., & Gunawan, H.A.
(2018). Antibacterial effect of Binahong
(Anredera cordifolia (Ten.) Steenis) leaf
infusion against black pigmented bacteria. J.
Phys.: Conf. Ser, 1073, 032013.
doi:10.1088/1742-6596/1073/3/032013
Patil, S., Bachhav, S., Bhutada, M., Patil, S., &
Sharma, K. (2015). Oleanolic acid prevents
increase in blood pressure and nephrotoxicity
in nitric oxide dependent type of
hypertension in rats. Pharmacognosy
Research, 7(4), 385. doi:10.4103/0974-
8490.159575
PIER. (2013). Anredera cordifolia: info from PIER
(PIER species info). Retrieved in 19 December
2020 from
http://www.hear.org/pier/species/anredera
_cordifolia.htm
Nagappan, R. (2012). Evaluation of aqueous and
ethanol extract of bioactive medicinal plant,
Cassia didymobotrya (Fresenius) Irwin &
Barneby against immature stages of filarial
vector, Culex quinquefasciatus Say (Diptera:
Culicidae). Asian Pacific Journal of Tropical
Biomedicine, 2(9), 707–711.
doi:10.1016/s2221-1691(12)60214-7
Nisar, B., Sultan, A., & Rubab, S. (2018).
Comparison of Medicinally Important Natural
Products versus Synthetic Drugs-A Short
Commentary. Natural Products Chemistry &
Research, 6(2). doi:10.4172/2329-
6836.1000308
Indonesian Journal of Life Sciences Vol. 03 | No. 02 | September 2021
http://journal.i3l.ac.id/index.php/IJLS
55
Nury, D. F., Widjaja, T., & Kurniawan, F. (2019).
The effect of Binahong (Anredera cordifolia
(Ten.) Steenis) medicinal plant extract
addition on glucose detection. Jurnal Sains
dan Seni ITS, 8(2), C15-C20.
doi:10.12962/j23373520.v8i2.49944
Serban, M., Sahebkar, A., Zanchetti, A.,
Mikhailidis, D., Howard, G., & Antal, D. et al.
(2016). Effects of quercetin on blood
pressure: a systematic review and meta‐
analysis of randomized controlled trials.
Journal of The American Heart Association,
5(7). doi:10.1161/jaha.115.002713
Setyowati, W.A.E.., Nurisah, R,P., & Wulandari,
P.I. (2020). Binahong leaves water extract
(Anredera Cordifolia (Tenore) Steen.) as a
natural foaming and antibacterial agent of
antiseptic liquid bath soap. JKPK (Jurnal Kimia
dan Pendidikan Kimia), 5(2).
doi:10.20961/jkpk.v5i2.29892
Sutrisno, E., Adnyana I, K., Yulinah Sukandar, E.,
Fidrianny, I., & Aligita, W. (2016). Antiinflammatory study of Anredera Cordifolia
leaves and Centella Asiatica herbs and its
combinations using human red blood cellmembrane stabilization method. Asian
Journal of Pharmaceutical and Clinical
Research, 9(5), 78. doi:10.22159/ajpcr.
2016.v9i5.11973
Syahfery, I., Nasution, A.H., Satria, D., Ervina, I.,
& Hanafiah, O.A. (2020). Evaluation of IL-6
levels after subgingival application Binahong
leaf extract gel 3% on patients of chronic
periodontitis. International Journal of Applied
Dental Sciences, 6(3), 615-618.
doi:10.22271/oral.2020.v6.i3i.1016
USDA. (2015). Plants Profile for Anredera
cordifolia (heartleaf madeiravine). Retrieved
in 19 December 2020 from
https://plants.usda.gov/core/profile?symbol
=anco6
Wahjuni, S. (2014). Anti-hipercholesterolemia of
Anredera cordifolia in hypercholesterolemia
rat wistar through decrease of
malondialdehyde and 8-hydroxydiguanosine. Indonesian Journal of
Biomedical Science, 8(1), 4-7.
doi:10.15562/ijbs.v8i1.7
Yang, R. L., Shi, Y. H., Hao, G., Li, W., & Le, G. W.
(2008). Increasing oxidative stress with
progressive hyperlipidemia in human:
relation between malondialdehyde and
atherogenic index. Journal of Clinical
Biochemistry and Nutrition, 43(3), 154-158.
doi:10.3164/jcbn.2008044
Yuniarti, W., & Lukiswanto, B. (2017). Effects of
herbal ointment containing the leaf extracts
of Madeira vine (Anredera cordifolia (Ten.)
Steenis) for burn wound healing process on
albino rats. Veterinary World, 10(7), 808-813.
doi:10.14202/vetworld.2017.808-813
Zhang, S., Liu, Y., Wang, X., Tian, Z., Qi, D., Li, Y.,
& Jiang, H. (2020). Antihypertensive activity
of oleanolic acid is mediated via
downregulation of secretory phospholipase
A2 and fatty acid synthase in spontaneously
hypertensive rats. International Journal of
Molecular Medicine, 46(6), 2019-2034.
doi:10.3892/ijmm.2020.4744
Published
2021-11-03
How to Cite
Salim, A., Kristanto, D., Subianto, F., Sundah, J., Jamaica, P., Angelika, T., & Maulida, N. (2021). Phytochemical Screening and Therapeutic Effects of Binahong (Anredera cordifolia (Ten.) Steenis) Leaves. Indonesian Journal of Life Sciences, 3(2), 43-55. https://doi.org/https://doi.org/10.54250/ijls.v3i2.125
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Indonesian Journal of Life Sciences
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