Meta-Analysis: Effectiveness of SSRIs vs SSRIs in conjunction with CBT in treating depression in young adolescents
Abstract
Objective: To compare the efficacy of SSRI medication alone and SSRI+CBT combined.
Methods: NCBI Pubmed, DARE, CSDR and NGC were searched October-November 2019. The population size, as well as the base and endpoint CGAS mean and standard deviation from the three studies included, are recorded. Statistical analysis was done in RStudio with the "meta" package.
Results: For the SSRI only, the effect size was -1.82 with a 95% confidence interval between -2.28 and -1.37. For the SSRI and CBT combined, the effect size was -1.68 with a 95% confidence interval between -2.39 and -0.98. The effect size for both SSRI and SSRI + CBT didn't cross the null effect line, but the heterogeneity exceeds 50%. The result for the comparison of post SSRI vs. SSRI + CBT showed the effect size of -0.05 with a 95% confidence interval between -0.23 and 0.12. The size effect did cross the null effect line, but the heterogeneity was less than 50%.
Conclusion: Both methods were shown to be effective. However, due to statistical inconsistencies, it couldn’t be concluded whether the combination of SSRI and CBT is better than treatment with SSRI alone.
Downloads
References
Clarke, G., Debar, L., Lynch, F., Powell, J., Gale, J., & O'Connor, E. et al. (2005). A Randomized Effectiveness Trial of Brief Cognitive-Behavioral Therapy for Depressed Adolescents Receiving Antidepressant Medication. Journal Of The American Academy Of Child & Adolescent Psychiatry, 44(9), 888-898. doi: 10.1016/s0890-8567(09)62194-8
Goodyer, I., Dubicka, B., Wilkinson, P., Kelvin, R., Roberts, C., & Byford, S. et al. (2007). Selective serotonin reuptake inhibitors (SSRIs) and routine specialist care with and without cognitive behaviour therapy in adolescents with major depression: randomised controlled trial. BMJ, 335(7611), 142. doi: 10.1136/bmj.39224.494340.55
Goodyer, I., Dubicka, B., Wilkinson, P., Kelvin, R., Roberts, C., & Byford, S. et al. (2008). A randomised controlled trial of cognitive behaviour therapy in adolescents with major depression treated by selective serotonin reuptake inhibitors. The ADAPT trial. Health Technology Assessment, 12(14). doi: 10.3310/hta12140
Thapar, A., Collishaw, S., Pine, D., & Thapar, A. (2012). Depression in adolescence. The Lancet, 379(9820), 1056-1067. doi: 10.1016/s0140-6736(11)60871-4
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Articles published in Indonesian Journal Life of Sciences are licensed under a Creative Commons Attribution-ShareAlike 4.0 International license. You are free to copy, transform, or redistribute articles for any lawful purpose in any medium, provided you give appropriate credit to the original author(s) and Indonesian Journal Life of Sciences, link to the license, indicate if changes were made, and redistribute any derivative work under the same license. Copyright on articles is retained by the respective author(s), without restrictions. A non-exclusive license is granted to Indonesian Journal Life of Sciences to publish the article and identify itself as its original publisher, along with the commercial right to include the article in a hardcopy issue for sale to libraries and individuals. By publishing in Indonesian Journal Life of Sciences, authors grant any third party the right to use their article to the extent provided by the Creative Commons Attribution-ShareAlike 4.0 International license.
