Thermal Stability of Human Milk Bioactives: A Global Bibliometric Overview

  • Dilma'aarij Riski Agustia Universitas Satya Terra Bhinneka, Medan, Indonesia
  • Bilqis Nur Mustofa Universitas Satya Terra Bhinneka, Medan, Indonesia
Keywords: Bibliometric analysis, Bioactive components, Global research, Human milk, Thermal stability

Abstract

Human milk is the optimal source of nutrition for infants, providing essential nutrients and bioactive components crucial for growth and development. However, these components are sensitive to post-expression handling, particularly thermal processes like storage, pasteurization, and heating. This study maps the global research landscape on the thermal stability of human milk bioactive components and identifies trends, key contributors, and research gaps. A bibliometric analysis was conducted using the Scopus database for publications from 2000 to 2023. The findings reveal a significant upward trend in publications over the last decade, with research predominantly led by the United States and China through strong international collaborations. While themes such as pasteurization and microbiological quality are well established, research on the thermal stability of non-protein bioactive components, inter-component interactions, and their long-term clinical impacts on infant health remains scarce. These results provide a foundation for developing evidence-based guidelines for human milk handling and highlight priority areas for future investigation.

Downloads

Download data is not yet available.

Author Biographies

Dilma'aarij Riski Agustia, Universitas Satya Terra Bhinneka, Medan, Indonesia

Department of Health, Universitas Satya Terra Bhinneka

Bilqis Nur Mustofa, Universitas Satya Terra Bhinneka, Medan, Indonesia

Department of Health, Universitas Satya Terra Bhinneka

References

Carr, L. E., Virmani, M. D., Rosa, F., Munblit, D., Matazel, K. S., Elolimy, A. A., & Yeruva, L. (2021). Role of Human Milk Bioactives on Infants ’ Gut and Immune Health. Frontiers in Immunology, 12(February), 1–17. https://doi.org/10.3389/fimmu.2021.604080
Chang, J., Chen, C., & Fang, L. (2013). Influence of Prolonged Storage Process , Pasteurization , and Heat Treatment on Biologically-active Human Milk Proteins. Pediatrics and Neonatology, 54(6), 360–366. https://doi.org/10.1016/j.pedneo.2013.03.018
Eramo, V., Carboni, C., & Botondi, R. (2025). Industrial pilot-scale study on the ripening and quality parameters of Toma Piemontese PDO raw milk cheese in ozone-controlled atmosphere. Wiley Online Library, 2025(June). https://doi.org/10.1002/jsfa.70013
Garcı, N. R., Escuder-vieco, D., Cruz, J. De, Lora, D., & Palla, C. (2012). Effect of Freezing Time on Macronutrients and Energy Content of Breastmilk. Breastfeeding Medicine, 7(4). https://doi.org/10.1089/bfm.2011.0079
Núñez-delgado, A., Mizrachi-chávez, V. M., Welti-chanes, J., Macher-quintana, S. T., & Chuck-hernández, C. (2024). Breast milk preservation : thermal and non-thermal processes and their effect on microorganism inactivation and the content of bioactive and nutritional compounds. Frontiers in Nutrition, February. https://doi.org/10.3389/fnut.2023.1325863
Peila, C., Moro, G. E., Bertino, E., Cavallarin, L., Giribaldi, M., Giuliani, F., Cresi, F., & Coscia, A. (2016). The Effect of Holder Pasteurization on Nutrients and Biologically-Active Components in Donor Human Milk : A Review. MDPI Journals, 8(8), 1–19. https://doi.org/10.3390/nu8080477
Pendyala, B., Vashisht, P., Chen, F., Sanchez, S. E., Comstock, B., & Omsland, A. (2023). Evaluating the UV-C sensitivity of Coxiella burnetii in skim milk using a bench-scale collimated beam system and comparative thermal sensitivity study by pasteurization. Frontiers in Food Science and Technology, November, 1–9. https://doi.org/10.3389/frfst.2023.1251069
Zhang, S., Hu, L., Xue, Y., Zhang, D., Zhang, Y., & Wang, S. (2023). Development of a real-time loop-mediated isothermal amplification method for monitoring Pseudomonas lurida in raw milk throughout the year of pasture. Frontiers in Microbiology, April, 1–12. https://doi.org/10.3389/fmicb.2023.1133077
Published
2026-09-30
How to Cite
Agustia, D. R., & Mustofa, B. N. (2026). Thermal Stability of Human Milk Bioactives: A Global Bibliometric Overview. Indonesian Journal of Life Sciences, 8(02), 69-78. https://doi.org/10.54250/ijls.v8i02.336
Section
Food Science and Nutrition