Comparative Analysis For CNN and MLP Models in Breast Cancer Diagnosis

  • Priscilla Natalie Nurtanio Universitas Prasetiya Mulya, Indonesia
  • Darren Nathaniel Universitas Prasetiya Mulya, Indonesia
  • Temmy Sugiarto Universitas Prasetiya Mulya, Indonesia
  • Theresa Angelina Universitas Prasetiya Mulya, Indonesia
  • Raymond Tjandra Universitas Prasetiya Mulya, Indonesia
  • Yohana Joevanca Kurniawan Universitas Prasetiya Mulya, Indonesia
  • Maria Zefanya Sampe Universitas Prasetiya Mulya, Indonesia
Keywords: Breast Cancer, Convolutional Neural Network, Diagnostic Accuracy, Hyperparameter Tuning, Multilayer Perceptron

Abstract

Breast cancer remains one of the most common and deadly diseases affecting women worldwide, highlighting the importance of early and accurate diagnosis to improve treatment outcomes and survival rates. However, traditional mammography techniques often fall short, failing to detect up to 20% of cases, especially in women with dense breast tissue, which makes detection more difficult. In response to these limitations, this study explores the use of neural networks to enhance diagnostic accuracy in breast cancer detection, focusing on the Convolutional Neural Network (CNN) and Multilayer Perceptron (MLP). Utilizing the Wisconsin Diagnostic Breast Cancer (WDBC) dataset, a baseline CNN model is compared against an optimized CNN refined through hyperparameter tuning using randomized search, as well as two MLP models implemented via Keras and Scikit-learn, along with their optimized versions. Each model is evaluated using key classification metrics, including accuracy, precision, recall, F1-score, and AUC, with an emphasis on minimizing false negatives, as this is critical in medical diagnosis to avoid missed malignancies. The results indicate that the optimized CNN model achieved near-perfect scores across all metrics and demonstrated the best balance between training and testing data. Therefore, it outperforms the baseline CNN and MLP models in significantly reducing false negatives, showcasing the potential of a well-tuned CNN to enhance the automation and reliability of breast cancer diagnostic processes.

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Author Biographies

Priscilla Natalie Nurtanio, Universitas Prasetiya Mulya, Indonesia

School of Applied STEM, Universitas Prasetiya Mulya, Jakarta

Darren Nathaniel, Universitas Prasetiya Mulya, Indonesia

School of Applied STEM, Universitas Prasetiya Mulya, Jakarta

Temmy Sugiarto, Universitas Prasetiya Mulya, Indonesia

School of Applied STEM, Universitas Prasetiya Mulya, Jakarta

Theresa Angelina, Universitas Prasetiya Mulya, Indonesia

School of Applied STEM, Universitas Prasetiya Mulya, Jakarta

Raymond Tjandra, Universitas Prasetiya Mulya, Indonesia

School of Applied STEM, Universitas Prasetiya Mulya, Jakarta

Yohana Joevanca Kurniawan, Universitas Prasetiya Mulya, Indonesia

School of Applied STEM, Universitas Prasetiya Mulya, Jakarta

Maria Zefanya Sampe, Universitas Prasetiya Mulya, Indonesia

School of Applied STEM, Universitas Prasetiya Mulya, Jakarta

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Published
2026-03-31
How to Cite
Nurtanio, P., Nathaniel, D., Sugiarto, T., Angelina, T., Tjandra, R., Kurniawan, Y., & Sampe, M. (2026). Comparative Analysis For CNN and MLP Models in Breast Cancer Diagnosis. Indonesian Journal of Life Sciences, 8(01), 1-20. https://doi.org/https://doi.org/10.54250/ijls.v8i01.254
Section
Biotechnology