Curcumin in Temulawak: Bioavailability, Health Benefits, and Potential Application
Abstract
Temulawak (Curcuma xanthorrhiza), a plant native to Indonesia, has long been utilized in traditional medicine and culinary applications for its rich bioactive profile. Curcumin, the primary bioactive compound, is well-known for its antioxidant, anti-inflammatory, and antimicrobial properties. This review aims to explore the challenges, benefits, and potential applications of curcumin in functional foods and pharmaceuticals. Although curcumin is known for its therapeutic properties in modulating inflammatory diseases, metabolic disorders, and cancer, its low water solubility and rapid metabolism limit its bioavailability. Current research has shown various strategies to enhance curcumin’s stability and absorption, including nanoemulsions, biopolymer encapsulation, and phytosome technology. However, despite its broad applications, optimization of curcumin’s industrial use remains a challenge. As advancements continue, curcumin’s role in product development and innovative applications across various industries should be further researched, with a focus on improving its solubility, controlled delivery systems, and compliance with food and pharmaceutical regulations.
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References
441-461. https://doi.org/10.1080/1028415X.2020.176053
Adamczak, A., Ożarowski, M., & Karpiński, T. M. (2020). Curcumin, a Natural Antimicrobial Agent with
Strain-Specific Activity. Pharmaceuticals, 13(7), 153. https://doi.org/10.3390/ph13070153
Ahmed, M. W., Haque, M. A., Mohibbullah, M., Khan, M. S. I., Islam, M. A., Mondal, M. H. T., &
Ahmmed, R. (2022). A review on active packaging for quality and safety of foods: Current
trends, applications, prospects and challenges. Food Packaging and Shelf Life, 33, 100913.
https://doi.org/10.1016/j.fpsl.2022.100913
Alam, S., Panda, J. J., Mukherjee, T. K., & Chauhan, V. S. (2016). Short peptide based nanotubes
capable of effective curcumin delivery for treating drug resistant malaria. Journal of
nanobiotechnology, 14, 1-14.
Alam, M. S., Anwar, M. J., Maity, M. K., Azam, F., Jaremko, M., & Emwas, A. (2024). The dynamic role
of curcumin in mitigating human illnesses: Recent advances in therapeutic applications.
Pharmaceuticals, 17(12), 1674. https://doi.org/10.3390/ph17121674
Ali, Z., Putri, M. D., Marlina, D., Sainita, N., & Asda, V. D. (2022). Bioinformatic Study Of The Active
Compound Curcuma Xanthorrhiza (Temulawak) In Preventing Cancer.
Anas, M., Falak, A., Khan, A., Khattak, W. A., Nisa, S. G., Aslam, Q., Khan, K. A., Saleem, M. H., & Shah
Fahad. (2024). Therapeutic potential and agricultural benefits of curcumin: a comprehensive
review of health and sustainability applications. Journal of Umm Al-Qura University for
Applied Sciences. https://doi.org/10.1007/s43994-024-00200-7
Appendino, G., Allegrini, P., de Combarieu, E., Novicelli, F., Ramaschi, G., & Sardone, N. (2021).
Shedding
light
on
curcumin
https://doi.org/10.1016/j.fitote.2021.105084
stability.
Fitoterapia,
156,
105084.
Aydin, B. S., Sagiroglu, A. A., Civelek, D. O., Gokce, M., & Bahadori, F. (2024). Development of
Curcumin and Turmerone Loaded Solid Lipid Nanoparticle for Topical Delivery: Optimization,
Characterization and Skin Irritation Evaluation with 3D Tissue Model. International Journal of
Nanomedicine, 19, 1951. https://doi.org/10.2147/IJN.S453347
Bertoncini-Silva, C., Vlad, A., Ricciarelli, R., Fassini, P. G., Suen, V. M. M., & Zingg, J. (2024). Enhancing
the bioavailability and bioactivity of curcumin for disease prevention and treatment.
Antioxidants, 13(3), 331. https://doi.org/10.3390/antiox13030331
Bhargav, E., Koteshwara, K., Padmanabha Reddy, Y., Sowmya, C., & Ramalingam, P. (2023).
Development of Curcumin nanophytosomes surface functionalized with Chondroitin
sulfate-A for treating k1 Plasmodium falciparum drug-resistant malaria. Journal of Drug
Delivery Science and Technology, 87, 104788. https://doi.org/10.1016/j.jddst.2023.104788
Bhat, A., Mahalakshmi, A. M., Ray, B., Tuladhar, S., Hediyal, T. A., Manthiannem, E., ... & Sakharkar, M.
K. (2019). Benefits of curcumin in brain disorders. BioFactors, 45(5), 666-689.
https://doi.org/10.1002/biof.1533
Bińkowska, W., Szpicer, A., Stelmasiak, A., Wojtasik-Kalinowska, I., & Półtorak, A. (2024).
Microencapsulation of polyphenols and their application in food technology. Applied
Sciences, 14(24), 11954. https://doi.org/10.3390/app142411954
Borgheti-Cardoso, L. N., San Anselmo, M., Lantero, E., Lancelot, A., Serrano, J. L., Hernández-Ainsa, S.,
... & Sierra, T. (2020). Promising nanomaterials in the fight against malaria. Journal of
Materials Chemistry B, 8(41), 9428-9448.
Chen, J., He, Z., Wang, F., Zhang, Z., Liu, X.-Z., Zhai, D.-D., & Chen, W. (2016). Curcumin and its promise
as an anticancer drug: An analysis of its anticancer and antifungal effects in cancer and
associated
complications
from
invasive
https://doi.org/10.1016/j.ejphar.2015.12.038
fungal
infections.
772,
33–42.
Chen, Y., Lu, Y., Lee, R. J., & Xiang, G. (2020). Nano encapsulated curcumin: and its potential for
biomedical applications. International Journal of Nanomedicine, 3099-3120.
Clark, R. L. (2019). Genesis of placental sequestration in malaria and possible targets for drugs for
placental malaria. Birth Defects Research, 111(10), 569-583.
Consoli, V., Sorrenti, V., Grosso, S., & Vanella, L. (2021). Heme oxygenase-1 signaling and redox
homeostasis
in
physiopathological
https://doi.org/10.3390/biom11040589
conditions.
Biomolecules,
11(4),
589.
Cozmin, M., Lungu, I. I., Gutu, C., Stefanache, A., Duceac, L. D., Șoltuzu, B. D., Damir, D., Calin, G.,
Goroftei, E. R. B., Grierosu, C., & Boev, M. (2024). Turmeric: from spice to cure. A review of
the anti-cancer, radioprotective and anti-inflammatory effects of turmeric sourced
compounds. Frontiers in Nutrition, 11. https://doi.org/10.3389/fnut.2024.1399888
Dai, C., Lin, J., Li, H., Shen, Z., Wang, Y., Velkov, T., & Shen, J. (2022). The Natural Product Curcumin as
an Antibacterial Agent: Current Achievements and Problems. Antioxidants, 11(3), 459.
https://doi.org/10.3390/antiox11030459
Dehzad, M. J., Ghalandari, H., Nouri, M., & Askarpour, M. (2023). Antioxidant and anti-inflammatory
effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic
review and dose–response meta-analysis of randomized controlled trials. Cytokine, 164,
156144. https://doi.org/10.1016/j.cyto.2023.156144
De Oliveira Filho, J. G., Bertolo, M. R. V., Rodrigues, M. Á. V., Marangon, C. A., Da Cruz Silva, G.,
Odoni, F. C. A., & Egea, M. B. (2021). Curcumin: A multifunctional molecule for the
development of smart and active biodegradable polymer-based films. Trends in Food Science
& Technology, 118, 840–849. https://doi.org/10.1016/j.tifs.2021.11.005
El-Saadony, M. T., Yang, T., Korma, S. A., Sitohy, M., Abd El-Mageed, T. A., Selim, S., Al Jaouni, S. K.,
Salem, H. M., Mahmmod, Y., Soliman, S. M., A Mosa, W. F., El-Wafai, N. A., Abou-Aly, H. E.,
Sitohy, B., Abd El-Hack, M. E., El-Tarabily, K. A., & Saad, A. M. (2023). Impacts of turmeric and
its principal bioactive curcumin on human health: Pharmaceutical, medicinal, and food
applications:
A comprehensive review. Frontiers in Nutrition, 9, 1040259.
https://doi.org/10.3389/fnut.2022.1040259
Esatbeyoglu, T., Ulbrich, K., Rehberg, C., Rohn, S., & Rimbach, G. (2015). Thermal stability,
antioxidant, and anti-inflammatory activity of curcumin and its degradation product 4-vinyl
guaiacol. Food & Function, 6(3), 887–893. https://doi.org/10.1039/c4fo00790e
Farzaei, M. H., Zobeiri, M., Parvizi, F., El-Senduny, F. F., Marmouzi, I., Coy-Barrera, E., ... & Abdollahi,
M. (2018). Curcumin in liver diseases: a systematic review of the cellular mechanisms of
oxidative
stress
and
clinical
https://doi.org/10.3390/nu10070855
perspective.
Nutrients,
10(7),
855.
Fernandes, R. V. D. B., Borges, S. V., Silva, E. K., Da Silva, Y. F., De Souza, H. J. B., Do Carmo, E. L., De
Oliveira, C. R., Yoshida, M. I., & Botrel, D. A. (2016). Study of ultrasound-assisted emulsions
on microencapsulation of ginger essential oil by spray drying. Industrial Crops and Products,
94, 413-423. https://doi.org/10.1016/j.indcrop.2016.09.010
Ferreira, N., Saraiva, M. J., & Almeida, M. R. (2019). Uncovering the neuroprotective mechanisms of
curcumin on transthyretin amyloidosis. International journal of molecular sciences, 20(6),
1287. https://doi.org/10.3390/ijms20061287
Fonseca-Santos, B., Gremião, M. P. D., & Chorilli, M. (2017). A simple reversed phase
high-performance liquid chromatography (HPLC) method for determination of in situ gelling
curcumin-loaded liquid crystals in in vitro performance tests. Arabian Journal of Chemistry,
10(7), 1029–1037. https://doi.org/10.1016/j.arabjc.2016.01.014
Gao, Y., Zhuang, Z., Lu, Y., Tao, T., Zhou, Y., Liu, G., ... & Hang, C. (2019). Curcumin mitigates
neuro-inflammation by modulating microglia polarization through inhibiting TLR4 axis
signaling pathway following experimental subarachnoid hemorrhage. Frontiers in
neuroscience, 13, 1223. https://doi.org/10.3389/fnins.2019.01223
Ghosh, S., Banerjee, S., & Sil, P. C. (2015). The beneficial role of curcumin on inflammation, diabetes
and neurodegenerative disease: A recent update. Food and Chemical Toxicology, 83,
111-124. https://doi.org/10.1016/j.fct.2015.05.022
Giordano, A., & Tommonaro, G. (2019). Curcumin and Cancer. Nutrients, 11(10), 2376.
https://doi.org/10.3390/nu11102376
Guo, J., Cao, X., Hu, X., Li, S., & Wang, J. (2020). The anti-apoptotic, antioxidant and
anti-inflammatory effects of curcumin on acrylamide-induced neurotoxicity in rats. BMC
Pharmacology and Toxicology, 21, 1-10. https://doi.org/10.1186/s40360-020-00440-3
Hashmi, M. F., & Cataletto, M. E. (2024, May 3). Asthma. PubMed; StatPearls Publishing.
https://www.ncbi.nlm.nih.gov/books/NBK430901/
Hewlings, S. J., & Kalman, D. S. (2017). Curcumin: A review of its effects on human health. Foods,
6(10), 92. https://doi.org/10.3390/foods6100092
Hossain, M. M., Islam, T., Jalil, M. A., Rakibuzzaman, S. M., Surid, S. M., Zabed, M. R. I., Talukder, A., &
Hossain, S. (2024b). Advancements of eco-friendly natural antimicrobial agents and their
transformative
role
in
sustainable
https://doi.org/10.1002/pls2.10135
textiles.
SPE Polymers, 5(3), 241–276.
Jacob, S., Kather, F. S., Morsy, M. A., Boddu, S. H., Attimarad, M., Shah, J., ... & Nair, A. B. (2024).
Advances in nanocarrier systems for overcoming formulation challenges of curcumin: current
insights. Nanomaterials, 14(8), 672.
Jakubczyk, K., Drużga, A., Katarzyna, J., & Skonieczna-Żydecka, K. (2020). Antioxidant Potential of
Curcumin—A Meta-Analysis of Randomized Clinical Trials. Antioxidants, 9(11), 1092.
https://doi.org/10.3390/antiox9111092
Jiang, T., Liao, W., & Charcosset, C. (2020). Recent advances in encapsulation of curcumin in
nanoemulsions: A review of encapsulation technologies, bioaccessibility and applications.
Food Research International, 132, 109035. https://doi.org/10.1016/j.foodres.2020.109035
Jin, T., Zhang, Y., Botchway, B. O., Zhang, J., Fan, R., Zhang, Y., & Liu, X. (2022). Curcumin can improve
Parkinson's disease via activating BDNF/PI3k/Akt signaling pathways. Food and Chemical
Toxicology, 164, 113091. https://doi.org/10.1016/j.fct.2022.113091
Kamal, D. A. M., Salamt, N., Yusuf, A. N. M., Kashim, M. I. A. M., & Mokhtar, M. H. (2021). Potential
health benefits of curcumin on female reproductive disorders: A review. Nutrients, 13(9),
3126. https://doi.org/10.3390/nu13093126
Kharat, M., Du, Z., Zhang, G., & McClements, D. J. (2017). Physical and Chemical Stability of Curcumin
in Aqueous Solutions and Emulsions: Impact of pH, Temperature, and Molecular
Environment. Journal of Agricultural and Food Chemistry, 65(8), 1525–1532.
https://doi.org/10.1021/acs.jafc.6b04815
Kotra, V. S. R., Satyabanta, L., & Goswami, T. K. (2019). A critical review of analytical methods for
determination of curcuminoids in turmeric. Journal of Food Science and Technology, 56(12),
5153–5166. https://doi.org/10.1007/s13197-019-03986-1
Kou, H., Huang, L., Jin, M., He, Q., Zhang, R., & Ma, J. (2023). Effect of curcumin on rheumatoid
arthritis: a systematic review and meta-analysis. Frontiers in Immunology, 14.
https://doi.org/10.3389/fimmu.2023.1121655
Kumari, A., Raina, N., Wahi, A., Goh, K. W., Sharma, P., Nagpal, R., ... & Gupta, M. (2022).
Wound-healing effects of curcumin and its nanoformulations: a comprehensive review.
Pharmaceutics, 14(11), 2288.
Lara-Espinoza, C., Carvajal-Millán, E., Balandrán-Quintana, R., López-Franco, Y., & Rascón-Chu, A.
(2018). Pectin and pectin-based composite materials: Beyond food texture. Molecules, 23(4),
942.
Lee, H., Kang, S., Jeong, S., Chung, K., & Kim, B. (2017). Antibacterial photodynamic therapy with
curcumin and Curcuma xanthorrhiza extract against Streptococcus mutans. Photodiagnosis
and Photodynamic Therapy, 20, 116-119. https://doi.org/10.1016/j.pdpdt.2017.09.003
Lim, M. A., & Pranata, R. (2020). The insidious threat of jamu and unregulated traditional medicines
in the COVID-19 era. Diabetes & Metabolic Syndrome Clinical Research & Reviews, 14(5),
895–896. https://doi.org/10.1016/j.dsx.2020.06.022
Liu, S., Liu, J., He, L., Liu, L., Cheng, B., Zhou, F., ... & He, Y. (2022). A comprehensive review on the
benefits and problems of curcumin with respect to human health. Molecules, 27(14), 4400.
https://doi.org/10.3390/molecules27144400
Lopresti, A. L. (2017). Curcumin for neuropsychiatric disorders: a review of in vitro, animal and
human
studies.
Journal
of
https://doi.org/10.1177/0269881116686883
Psychopharmacology,
31(3),
287-302.
Lopresti, A. L. (2022). Potential role of curcumin for the treatment of major depressive disorder. CNS
drugs, 36(2), 123-141. https://doi.org/10.1007/s40263-022-00901-9
Memarzia, A., Khazdair, M. R., Behrouz, S., Gholamnezhad, Z., Jafarnezhad, M., Saadat, S., &
Boskabady, M. H. (2021). Experimental and clinical reports on anti-inflammatory, antioxidant,
and immunomodulatory effects of Curcuma longa and curcumin, an updated and
comprehensive review. BioFactors, 47(3), 311-350. https://doi.org/10.1002/biof.1716
Moghaddam, N. S. A., Oskouie, M. N., Butler, A. E., Petit, P. X., Barreto, G. E., & Sahebkar, A. (2019).
Hormetic effects of curcumin: What is the evidence?. Journal of cellular physiology, 234(7),
10060-10071. https://doi.org/10.1002/jcp.27880
Mucha, P., Skoczyńska, A., Małecka, M., Hikisz, P., & Budzisz, E. (2021). Overview of the Antioxidant
and Anti-Inflammatory Activities of Selected Plant Compounds and Their Metal Ions
Complexes. Molecules, 26(16), 4886. https://doi.org/10.3390/molecules26164886
Mukti, L. S., & Hermady, U. (2020). PHARMACOLOGICAL ACTIVITIES OF CURCUMA XANTHORRHIZA.
Jurnal Info Kesehatan , 10(1).
Novak-Bilić, G., Vučić, M., Japundžić, I., Meštrović-Štefekov, J., Stanić-Duktaj, S., & Lugović-Mihić, L.
(2018). Irritant and allergic contact dermatitis–skin lesion characteristics. Acta Clinica
Croatica, 57(4.), 713-719.
Novianti, D., & Kartika, T. (2019, November). Fractionation of bioactive materials temulawak rhizome
(Curcuma xanthorrhiza) on fungal Candida albicans in search of phytopharmaca. In Journal of
Physics: Conference Series (Vol. 1375, No. 1, p. 012015). IOP Publishing.
Nugroho, A. K., Kusumorini, N., Pramono, S., & Martien, R. (2023). An update on nanoparticle
formulation design of piperine to improve its oral bioavailability: a review. Iraqi Journal of
Pharmaceutical Sciences, 32(1), 14-30. https://doi.org/10.31351/vol32iss1pp14-30
Nurcholis, W., Munshif, A. A., & Ambarsari, L. (2018). Xanthorrhizol contents, α-glucosidase
inhibition, and cytotoxic activities in ethyl acetate fraction of Curcuma zanthorrhiza
accessions from Indonesia. Revista Brasileira de Farmacognosia, 28, 44-49.
Oliveira Filho, J. G. D., Bertolo, M. R. V., Rodrigues, M. Á. V., Marangon, C. A., Silva, G. D. C., Odoni, F.
C. A., & Egea, M. B. (2021). Curcumin: A multifunctional molecule for the development of
smart and active biodegradable polymer-based films. Trends in Food Science & Technology,
118, 840-849. https://doi.org/10.1016/j.tifs.2021.11.005
Oliveira Filho, J. G., & Egea, M. B. (2022). Edible Bioactive Film with Curcumin: A Potential
“Functional” Packaging? International Journal of Molecular Sciences, 23(10), 5638.
https://doi.org/10.3390/ijms23105638
Oliveira, J. T., & Pieniz, S. (2024). Curcumin in Alzheimer’s Disease and depression: therapeutic
potential and mechanisms of action. Brazilian Archives of Biology and Technology, 67,
e24220004. https://doi.org/10.1590/1678-4324-2024220004
Pan, S., Yan, J., Xu, X., Chen, Y., Chen, X., Li, F., & Xing, H. (2022). Current development and future
application prospects of plants-derived polyphenol bioactive substance curcumin as a novel
feed additive in livestock and poultry. International Journal of Molecular Sciences, 23(19),
11905. https://doi.org/10.3390/ijms231911905
Pan-On, S., & Tiyaboonchai, W. (2023). Development, characterization and Caco-2 cells absorption of
curcumin solid dispersion for oral administration. Journal of Drug Delivery Science and
Technology, 86, 104574. https://doi.org/10.1016/j.jddst.2023.104574
Pancholi, V., Smina, T. P., Kunnumakkara, A. B., Maliakel, B., & Krishnakumar, I. M. (2021). Safety
assessment of a highly bioavailable curcumin-galactomannoside complex (CurQfen) in
healthy volunteers, with a special reference to the recent hepatotoxic reports of curcumin
supplements: A 90-days prospective study. Toxicology Reports, 8, 1255-1264.
https://doi.org/10.1016/j.toxrep.2021.06.008
Panda, A. K., Chakraborty, D., Sarkar, I., Khan, T., & Sa, G. (2017). New insights into therapeutic
activity and anticancer properties of curcumin. Journal of experimental pharmacology, 31-45.
https://doi/full/10.2147/JEP.S70568
Peanparkdee, M., Iwamoto, S., & Yamauchi, R. (2016). Microencapsulation: a review of applications
in the food and pharmaceutical industries. Reviews in Agricultural Science, 4, 56-65.
Peng, Y., Ao, M., Dong, B., Jiang, Y., Yu, L., Chen, Z., ... & Xu, R. (2021). Anti-inflammatory effects of
curcumin in the inflammatory diseases: status, limitations and countermeasures. Drug
design, development and therapy, 4503-4525. https://doi.org/10.2147/DDDT.S327378
Peram, M. R., Jalalpure, S. S., Palkar, M. B., & Diwan, P. V. (2017). Stability studies of pure and mixture
form of curcuminoids by reverse phase-HPLC method under various experimental stress
conditions.
Food
Science
and
https://doi.org/10.1007/s10068-017-0087-1
Biotechnology,
26(3),
591–602.
Perrone, D., Ardito, F., Giannatempo, G., Dioguardi, M., Troiano, G., Lo Russo, L., ... & Lo Muzio, L.
(2015). Biological and therapeutic activities, and anticancer properties of curcumin.
Experimental
and
therapeutic
https://doi.org/10.3892/etm.2015.2749
medicine,
10(5),
1615-1623.
Prasad, S., DuBourdieu, D., Srivastava, A., Kumar, P., & Lall, R. (2021). Metal–Curcumin Complexes in
Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin. International
Journal of Molecular Sciences, 22(13), 7094. https://doi.org/10.3390/ijms22137094
Pondini, N. D. A., Rosyadi, N. E. H., Azzahro, N. G. N., Fariha, N. I., Pitaloka, L., Akbar, N. M. R., &
Yuniarsih, N. N. (2023). The potential of turmeric rhizome extract in the preparation of
cosmetic creams and lotions: A systematic literature review. Eureka Herba Indonesia, 4(2),
232–236. https://doi.org/10.37275/ehi.v4i2.74
Quan, M., Alismail, A., Daher, N., Cleland, D., Chavan, S., & Tan, L. D. (2021). Randomized, placebo
controlled, double blinded pilot superiority phase 2 trial to evaluate the effect of curcumin in
moderate
to
severe
asthmatics.
https://doi.org/10.1186/s12890-021-01619-y
BMC Pulmonary Medicine, 21(1).
Rahmat, E., Lee, J., & Kang, Y. (2021). Javanese Turmeric (Curcuma xanthorrhiza Roxb.): Ethnobotany,
Phytochemistry,
Complementary
Biotechnology,
and
and Pharmacological Activities. Evidence-Based
Alternative
https://doi.org/10.1155/2021/9960813
Medicine,
2021,
1–15.
Rosidi, A., Hidayah, Y., Latrobdiba, Z. M., Setyawati, Y. N., Ulvie, A. I., Sulistyaningrum, H., &
Sulistyowati, E. (2024, October). Response of White Rat (Rattus Norvegicus) Leukocyte
Numbers with Temulawak (Curcuma Xanthorrhiza Roxb) Extract in Severe Exercise. In
Proceedings of the 2nd Lawang Sewu International Symposium on Health Sciences:
Nutrition:(LSISHSN 2023) (Vol. 80, p. 90). Springer Nature.
Roy, S., Priyadarshi, R., Ezati, P., & Rhim, J. (2022). Curcumin and its uses in active and smart food
packaging applications - a comprehensive review. Food Chemistry, 375, 131885.
https://doi.org/10.1016/j.foodchem.2021.131885
Ruiz de Porras, V., Figols, M., Font, A., & Pardina, E. (2023). Curcumin as a hepatoprotective agent
against
chemotherapy-induced
liver
https://doi.org/10.1016/j.lfs.2023.122119
injury.
Life
Sciences,
332,
122119.
Saini, A., Kumar, M., Bhatt, S., Saini, V., & Malik, A. (2020). Cancer causes and treatments. Int J Pharm
Sci Res, 11(7), 3121-3134.
Salsabila, H. U. L. W. A., Fitriani, L. I. L. I., & Zaini, E. R. I. Z. A. L. (2021). Recent strategies for
improving solubility and oral bioavailability of piperine. Int. J. Appl. Pharm, 13(4), 31-39.
https://dx.doi.org/10.22159/ijap.2021v13i4.41596
Schaefer, D., & Cheung, W. M. (2017). Smart Packaging: Opportunities and Challenges. Procedia CIRP,
72, 1022-1027. https://doi.org/10.1016/j.procir.2018.03.240
Shahrajabian, M. H., & Sun, W. (2024). The golden spice for life: turmeric with the pharmacological
benefits of curcuminoids components, including curcumin, bisdemethoxycurcumin, and
demethoxycurcumins. Current Organic Synthesis, 21(5), 665-683.
Sharifi-Rad, J., Rayess, Y. E., Rizk, A. A., Sadaka, C., Zgheib, R., Zam, W., ... & Martins, N. (2020).
Turmeric and its major compound curcumin on health: bioactive effects and safety profiles
for food, pharmaceutical, biotechnological and medicinal applications. Frontiers in
pharmacology, 11, 550909. https://doi.org/10.3389/fphar.2020.01021
Silvestro, S., Sindona, C., Bramanti, P., & Mazzon, E. (2021). A state of the art of antioxidant
properties of curcuminoids in neurodegenerative diseases. International journal of molecular
sciences, 22(6), 3168. https://doi.org/10.3390/ijms22063168
Simunkova, M., Alwasel, S. H., Alhazza, I. M., Jomova, K., Kollar, V., Rusko, M., & Valko, M. (2019).
Management of oxidative stress and other pathologies in Alzheimer’s disease. Archives of
Toxicology, 93(9), 2491-2513. https://doi.org/10.1007/s00204-019-02538-y
Surya, R., Romulo, A., Nurkolis, F., & Kumalawati, D. A. (2024b). Compositions and health benefits of
different types of jamu, traditional medicinal drinks popular in Indonesia. In Reference series
in phytochemistry (pp. 307–339). https://doi.org/10.1007/978-3-031-38663-3_123
Syamsudin, R. A. M. R., Perdana, F., Mutiaz, F. S., Galuh, V., Rina, A. P. A., Cahyani, N. D., Aprilya, S.,
Yanti, R., & Khendri , F. (2019). TEMULAWAK PLANT (Curcuma xanthorrhiza Roxb) as a
TRADITIONAL MEDICINE.
Tabanelli, R., Brogi, S., & Calderone, V. (2021). Improving curcumin bioavailability: Current strategies
and
future
perspectives.
Pharmaceutics,
https://doi.org/10.3390/pharmaceutics13101715
13(10),
1715.
Tang, M., & Taghibiglou, C. (2017). The mechanisms of action of curcumin in Alzheimer’s disease.
Journal of Alzheimer’s disease, 58(4), 1003-1016. https://doi.org/10.3233/JAD-170188
Toden, S., Theiss, A. L., Wang, X., & Goel, A. (2017). Essential turmeric oils enhance anti-inflammatory
efficacy of curcumin in dextran sulfate sodium-induced colitis. Scientific Reports, 7(1), 1-12.
https://doi.org/10.1038/s41598-017-00812-6
Viscusi, G., Lamberti, E., Angilè, F., Di Stasio, L., Gerardi, C., Giovinazzo, G., Vigliotta, G., & Gorrasi, G.
(2025). Smart pH-sensitive indicators based on rice starch/pectin/alginate loading Lambrusco
pomace extract and curcumin to track the freshness of pink shrimps. International Journal of
Biological Macromolecules, 291, 139085. https://doi.org/10.1016/j.ijbiomac.2024.139085
Wang, X. S., Zhang, Z. R., Zhang, M. M., Sun, M. X., Wang, W. W., & Xie, C. L. (2017). Neuroprotective
properties of curcumin in toxin-base animal models of Parkinson’s disease: a systematic
experiment literatures review. BMC complementary and alternative medicine, 17, 1-10.
https://doi.org/10.1186/s12906-017-1922-x
Wolnicka-Glubisz, A., & Wisniewska-Becker, A. (2023). Dual Action of Curcumin as an Anti- and
Pro-Oxidant from a Biophysical Perspective. Antioxidants, 12(9), 1725–1725.
https://doi.org/10.3390/antiox12091725
Yonata, D., Ulvie, Y. N. S., Soesanto, E., Sulistyowati, E., Pranata, B., & Rosidi, A. (2025). Stabilization
and Controlled Release of Curcumin from Temulawak by Spray-Drying Microencapsulation
with Composite Wall Materials. Trends in Sciences, 22(2), 9125-9125.
Yosipovitch, G., Misery, L., Proksch, E., Metz, M., Ständer, S., & Schmelz, M. (2019). Skin Barrier
Damage and Itch: Review of Mechanisms, Topical Management and Future Directions. Acta
dermato-venereologica, 99(13).
Zhai, K., Brockmüller, A., Kubatka, P., Shakibaei, M., & Büsselberg, D. (2020). Curcumin’s Beneficial
Effects on Neuroblastoma: Mechanisms, Challenges, and Potential Solutions. Biomolecules,
10(11), 1469. https://doi.org/10.3390/biom10111469
Zhai, S. S., Ruan, D., Zhu, Y. W., Li, M. C., Ye, H., Wang, W. C., & Yang, L. (2020). Protective effect of
curcumin on ochratoxin A–induced liver oxidative injury in duck is mediated by modulating
lipid metabolism and the intestinal microbiota. Poultry Science, 99(2), 1124-1134.
https://doi.org/10.1016/j.psj.2019.10.041
Zheng, B., & McClements, D. J. (2020). Formulation of More Efficacious Curcumin Delivery Systems
Using Colloid Science: Enhanced Solubility, Stability, and Bioavailability. Molecules, 25(12),
2791. https://doi.org/10.3390/molecules25122791
Zhong, W., Qian, K., Xiong, J., Ma, K., Wang, A., & Zou, Y. (2016). Curcumin alleviates
lipopolysaccharide induced sepsis and liver failure by suppression of oxidative stress-related
inflammation via PI3K/AKT and NF-κB related signaling. Biomedicine & Pharmacotherapy, 83,
302-313. https://doi.org/10.1016/j.biopha.2016.06.036
Zhu, T., Chen, Z., Chen, G., Wang, D., Tang, S., Deng, H., Wang, J., Li, S., Lan, J., Tong, J., Li, H., Deng,
X., Zhang, W., Sun, J., Tu, Y., Luo, W., & Li, C. (2019). Curcumin Attenuates Asthmatic Airway
Inflammation and Mucus Hypersecretion Involving a PPARγ-Dependent NF-κB Signaling
Pathway In Vivo and In Vitro. Mediators of Inflammation, 2019, 1–15.
https://doi.org/10.1155/2019/4927430
Zielinski, R., Searing, K., & Deibel, M. (2015). Gastrointestinal distress in pregnancy: prevalence,
assessment, and treatment of 5 common minor discomforts. The Journal of perinatal &
neonatal nursing, 29(1), 23-31. https://doi.org/10.1097/JPN.0000000000000078
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