Implementation of Biodesign process to Identify Unmet Needs of Tuberculosis Patients in Indonesia

  • Melinda Siswanto Indonesia International Institute for Life Sciences
  • Gabriella Thimoty Student Indonesia International Institute for Life Sciences
  • Jonathan Hendrik Bera Student Indonesia International Institute for Life Sciences
Keywords: Biodesign, eradication, healthcare, tuberculosis, vaccine


Tuberculosis (TB) is an infectious disease mainly caused by Mycobacteria tuberculosis. It affects the respiratory system and may spread to the other organ. Due to the nature of the bacteria, infection of this species may cause a long-term TB, causing it a challenge for a full clearance. The disease has existed throughout the history, and BCG vaccine has been developed to control the spreading. Most developed countries have successfully eradicated TB. However, Indonesia is currently ranked second place for this disease, making it as a pressing matter to eradicate. This study is conducted to investigate and gather deep insights about the problems in eradicating TB in Indonesia. Identify part of the biodesign method is employed in the study to elucidate the complexity of healthcare issue of TB in Indonesia. The study discovered that there are three pillars’ sectors need to be addressed: education, healthcare facilities and services, and government. For successful eradication, synergistic approach to all pillars at the same time are essential. The needs statements formulated in this study could be the stem of innovation in TB.


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Author Biographies

Melinda Siswanto, Indonesia International Institute for Life Sciences

Biomedicine, I3L, Jakarta, Indonesia

Gabriella Thimoty, Student Indonesia International Institute for Life Sciences

Biomedicine, I3L, Jakarta, Indonesia

Jonathan Hendrik Bera, Student Indonesia International Institute for Life Sciences

Biomedicine, I3L, Jakarta, Indonesia


Acharya, B., Acharya, A., Gautam, S., Ghimire, S. P., Mishra, G., Parajuli, N., & Sapkota, B. (2020). Advances in diagnosis of Tuberculosis: an update into molecular diagnosis of Mycobacterium tuberculosis. Molecular Biology Reports, 47(5), 4065–4075. doi:10.1007/s11033-020-05413-7
Akbar, H., Kahloon, R., Akbar, S., & Kahloon, A. (2020). Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Mimicking as Pulmonary Tuberculosis in an Inmate. Cureus. doi:10.7759/cureus.8464
BañUls, A. L., Sanou, A., Van Anh, N. T., & Godreuil, S. (2015, November 1). Mycobacterium tuberculosis: Ecology and evolution of a human bacterium. Journal of Medical Microbiology.doi:10.1099/jmm.0.000171
Crisan-Dabija, R., Grigorescu, C., Pavel, C. A., Artene, B., Popa, I. V., Cernomaz, A., & Burlacu, A. (2020). Tuberculosis and COVID-19: Lessons from the Past Viral Outbreaks and Possible Future Outcomes. Canadian Respiratory Journal. doi:10.1155/2020/1401053
Dockrell, H. M., & Smith, S. G. (2017, September 13). What have we learnt about BCG vaccination in the last 20 years? Frontiers in Immunology. Frontiers Media S.A. doi:10.3389/fimmu.2017.01134
Heemskerk, D., Caws, M., Marais, B., & Farrar, J. (2015). Tuberculosis in Adults and Children (Vol. 2). Cham: Springer International Publishing. doi:10.1007/978-3-319-19132-4
Kemenkes RI. (2019). Situasi TBC di Indonesia. Retrieved January 29, 2021, from
Keshavjee, S., & Farmer, P. E. (2012). Tuberculosis, Drug Resistance, and the History of Modern Medicine. New England Journal of Medicine, 367(10), 931–936. doi:10.1056/nejmra1205429
Murtiwi, M. (2014). Keberadaan Pengawas Minum Obat (Pmo) Pasien Tuberkulosis Paru Di Indonesia. Jurnal Keperawatan Indonesia, 10(1), 11–15. doi:10.7454/jki.v10i1.167
Organization, W. H. (2015). Global Tuberculosis Report 2015. World Health Organization (Vol. 20th ed.). WHO. Retrieved from
Organization, W. H. (2020). GLOBAL TUBERCULOSIS REPORT 2020. WHO. Retrieved from
Pai, M., Behr, M. A., Dowdy, D., Dheda, K., Divangahi, M., Boehme, C. C., … Raviglione, M. (2016, October 27). Tuberculosis. Nature Reviews Disease Primers. Nature Publishing Group. doi:10.1038/nrdp.2016.76
Surya, A., Setyaningsih, B., Suryani Nasution, H., Gita Parwati, C., Yuzwar, Y. E., Osberg, M., … Waworuntu, W. (2017). Quality Tuberculosis Care in Indonesia: Using Patient Pathway Analysis to Optimize Public-Private Collaboration. Journal of Infectious Diseases, 216(suppl_7), S724–S732. doi:10.1093/infdis/jix379
Yang, H., & Lu, S. (2020). COVID-19 and tuberculosis. Journal of Translational Internal Medicine. doi:10.2478/jtim-2020-0010
Zenios, S., Makower, J., Yock, P., Brinton, T. J., Kumar, U. N., Denend, L., & Krummel, T. M. (2009). Biodesign. Biodesign. Cambridge University Press. doi:10.1017/cbo9780511757853
Zuiga, J., Torres-García, D., Santos-Mendoza, T., Rodriguez-Reyna, T. S., Granados, J., & Yunis, E. J. (2012). Cellular and humoral mechanisms involved in the control of tuberculosis. Clinical and Developmental Immunology. Hindawi Limited. doi:10.1155/2012/193923
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